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PHR1134

Supelco

Thymol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-Isopropyl-5-methylphenol, 5-Methyl-2-(1-methylethyl)phenol, 5-Methyl-2-isopropylphenol, IPMP

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About This Item

Linear Formula:
2-[(CH3)2CH]C6H3-5-(CH3)OH
CAS Number:
Molecular Weight:
150.22
Beilstein:
1907135
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1449008

vapor pressure

1 mmHg ( 64 °C)

API family

thymol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

232 °C (lit.)

mp

48-51 °C (lit.)

density

0.965 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)c1ccc(C)cc1O

InChI

1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3

InChI key

MGSRCZKZVOBKFT-UHFFFAOYSA-N

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thymol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0147 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

240.8 °F - closed cup

Flash Point(C)

116 °C - closed cup


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Spectrophotometric determination of thymol in pharmaceuticals with Gibb's reagent
Al-Neaimy, Usra IS
Journal of Educational Psychology, 22(39) (2009)
Antibacterial and antifungal activities of thymol: A brief review of the literature
Marchese A, et al.
Food Chemistry, 210, 402-414 (2016)
Spectrophotometric Determination of Thymol in Pharmaceuticla Formulations Via Oxidative Coupling Reaction
Mohammad, I Kh
Reactive functional Polymers, 17(3) (2005)
S P Lee et al.
British journal of pharmacology, 153(8), 1739-1749 (2008-03-13)
Thymol, a major component of thyme and oregano, has medical uses in oral care products as an astringent and antibiotic. Its distinctive sharp odour and pungent flavour are considered aversive properties. The molecular basis of these aversive properties is not
R Attin et al.
Archives of oral biology, 48(7), 503-509 (2003-06-12)
The objective of the present prospective trial was to compare the efficacy of differently concentrated chlorhexidine varnishes (EC40) = 40% chlorhexidine and Cervitec = 1% chlorhexidine + 0.1% thymol) on levels of Mutans streptococci (ms), lactobacilli (lb) and plaque formation

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