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Supelco

Tetrahydrocurcumin

analytical standard

Synonym(s):

1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione

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About This Item

Empirical Formula (Hill Notation):
C21H24O6
CAS Number:
36062-04-1
Molecular Weight:
372.41
Beilstein:
3485469
MDL number:
MFCD04152347
UNSPSC Code:
85151701
PubChem Substance ID:
329757577
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

SMILES string

COc1cc(CCC(=O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O

InChI

1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3

InChI key

LBTVHXHERHESKG-UHFFFAOYSA-N

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General description

Tetrahydrocurcumin is a colorless compound and a major metabolite of curcumin, which is known to possess antioxidant activity and inhibitory effects on tertiary butyl hydroperoxide-induced lipid peroxidation. It can be obtained via hydrogenation of curcumin in the presence of platinum(IV)oxide.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: curcuma

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

385.2 °F

Flash Point(C)

196.2 °C

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM5162
BCCK9277
BCCK0025
BCCG1967
BCCC5515

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Dharmendr Matabudul et al.
Anticancer research, 32(10), 4359-4364 (2012-10-13)
This study interrogated whether different durations of intravenous infusions of lipocurc™ would alter curcumin metabolism, tissue distribution and whether treating necropsied tissues of Beagle dogs with phosphoric acid prior to measuring curcumin and its metabolite, tetrahydrocurcumin (THC), would stabilize the
Dong Hoon Shin et al.
Biochemical and biophysical research communications, 428(1), 56-61 (2012-10-13)
Ca(2+) influx through Ca(2+)-release activated Ca(2+) channels (CRAC) is critical for activating immune cells. Orai and STIM proteins comprise the molecular components of CRAC. We previously observed that curcumin and caffeic acid phenethyl ester (CAPE) inhibit CRAC current in Orai1/STIM1-co-expressing
Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity
Pari L and Murugan P
Pharmacological Research, 49, 481-486 (2004)
Saipin Setthacheewakul et al.
AAPS PharmSciTech, 12(1), 152-164 (2010-12-25)
The objectives of this study were to develop and evaluate a novel self-emulsifying floating drug delivery system (SEFDDS) that resulted in improved solubility, dissolution, and controlled release of the poorly water-soluble tetrahydrocurcumin (THC). The formulations of liquid self-emulsifying drug delivery
Leelavinothan Pari et al.
Molecular and cellular biochemistry, 341(1-2), 109-117 (2010-03-27)
The present study evaluates the combined effect of tetrahydrocurcumin and chlorogenic acid on oxidative stress in streptozotocin-nicotinamide-induced diabetic rats. Rats were rendered diabetic by a single intraperitoneal injection (i.p) of streptozotocin (45 mg/kg BW), 15 min after an i.p injection
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