8.56186
Fmoc-Lys(ivDde)-Wang resin (100-200 mesh)
Novabiochem®
Synonym(s):
Fmoc-Protected Lysine Resin
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About This Item
UNSPSC Code:
12352209
NACRES:
NA.22
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General description
Useful tool for the synthesis of side-chain modified, cyclic and branched peptides by Fmoc SPPS. Following chain extension, the side-chain ivDde group is removed with 2% hydrazine in DMF, enabling selective modification of the ε-lysine amino group.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
SelectingOrthogonal Building Blocks
Literature references:
[1] R. Chhabra, et al. (1998) Tetrahedron Lett., 39, 1603.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
SelectingOrthogonal Building Blocks
Literature references:
[1] R. Chhabra, et al. (1998) Tetrahedron Lett., 39, 1603.
Application
Fmoc-Lys(ivDde)-Wang resin (100-200 mesh) has been used as a solid support to prepare a peptide bearing a hexacarbonyldiiron cluster, neoglycopeptides and lipopeptides as putative antifungal and cancer vaccines, respectively.
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene -1 % DVB), 100- 200 mesh.
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene -1 % DVB), 100- 200 mesh.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
An appraisal of new variants of Dde amine protecting group for solid phase peptide synthesis
R. Chhabra, et al.
Tetrahedron Letters, 39, 1603-1603 (1998)
Towards a fully synthetic MUC1-based anticancer vaccine: Efficient conjugation of glycopeptides with mono-, di-, and tetravalent lipopeptides using click chemistry
Cai H, et al.
Chemistry?A European Journal , 17, 6396-6406 (2011)
Artificial [FeFe]-Hydrogenase: On Resin Modification of an Amino Acid to Anchor a Hexacarbonyldiiron Cluster in a Peptide Framework
Roy S, et al.
European Journal of Inorganic Chemistry, 1050-1055 (2011)
Jonathan Cartmell et al.
Carbohydrate research, 403, 123-134 (2014-08-16)
Selective strategies for the construction of novel three component glycoconjugate vaccines presenting Candida albicans cell wall glycan (β-1,2 mannoside) and polypeptide fragments on a tetanus toxoid carrier are described. The first of two conjugation strategies employed peptides bearing an N-terminal
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