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1.02307

Sigma-Aldrich

α-Chymotrypsin from bovine pancreas

cryst. lyophilized 350 U/mg for biochemistry

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.21

form

solid

potency

>4000 mg/kg LD50, oral (rat)

pH

3-5 (10 g/L in H2O)

storage temp.

2-8°C

General description

α-Chymotrypsin (CT) is a member of the S1 family. It comprises a catalytic triad system including aspartate, histidine, and serine. It is produced by chymotrypsinogen in the pancreas and then secreted into the digestive tract.

Application

α-Chymotrypsin has been used to study its adsorption characteristics on solid/liquid interfaces under varying adsorption conditions.

Biochem/physiol Actions

α-Chymotrypsin (CT) closely denotes a group of digestive enzymes (trypsin, elastase) that hydrolyzes polypeptide chains. The catalytic triad system works together to regulate the nucleophilicity of the serine residue in catalysis. CT shows a capability to catalyze nonconventional synthetic reactions in water-miscible organic media. Additionally, it is also used as a tool in comparative studies of water-miscible and water-immiscible solvents.

Features and Benefits

  • Easily obtainable due to small size
  • Relatively stable

Analysis Note

Appearance (description):lyophilisate
Appearance (colour):slightly yellowish
Activity (ATEE, pH 8.0, 25 °C):≥ 350 U/mg
Spec. activity (calc. on protein):ca. 400

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1


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