159425
9-Chloroacridine
97%
Synonym(s):
9-Chloroacridine
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About This Item
Empirical Formula (Hill Notation):
C13H8ClN
CAS Number:
Molecular Weight:
213.66
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
97%
form
solid
mp
116-120 °C (lit.)
SMILES string
Clc1c2ccccc2nc3ccccc13
InChI
1S/C13H8ClN/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H
InChI key
BPXINCHFOLVVSG-UHFFFAOYSA-N
Application
9-Chloroacridine was employed as chromogenic reagent in the spectrophotometric method for the quantitative determination of dapsone. It was also used in the synthesis of:
- series of novel chalcones bearing acridine moiety attached to the amino group in their ring A
- new acridine derivatives
- 9-phenoxyacridine and 4-phenoxyfuro[2,3-b]quinoline derivatives
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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I Shoukrallah et al.
Die Pharmazie, 45(9), 675-677 (1990-09-01)
A spectrophotometric method for the quantitative determination of dapsone (1) has been developed through a condensation reaction of 9-chloroacridine as a chromogen and the amino groups of 1. The reaction variables were investigated and optimized. The resultant colored products is
Arumugasamy Elangovan et al.
Organic & biomolecular chemistry, 2(21), 3113-3118 (2004-10-27)
Electrogenerated chemiluminescence (ECL) of six new ethyne-based acridine derivatives (1-6) has been studied. The new acridine derivatives were synthesized by cross-coupling of 9-chloroacridine and corresponding donor-substituted phenylethynes under modified Sonogashira conditions. The donor groups were varied in the order of
V Tomar et al.
European journal of medicinal chemistry, 45(2), 745-751 (2009-12-22)
A series of novel chalcones bearing acridine moiety attached to the amino group in their ring A have been synthesized through noncatalyzed nucleophilic aromatic substitution reaction between various 3'-aminochalcone or 4'-aminochalcones and 9-chloroacridine. The synthesized chalcone derivatives have been characterized
Jelena Rupar et al.
Bioelectrochemistry (Amsterdam, Netherlands), 135, 107579-107579 (2020-06-14)
The electrochemical behavior of 9-chloroacridine (9Cl-A), a precursor molecule for synthesis of acridine derivatives with cytostatic activity, is a complex, pH-dependent, diffusion-controlled irreversible process. Oxidation of 9Cl-A initiates with the formation of a cation radical monomer, continues via the formation
Paula Bosch et al.
Materials (Basel, Switzerland), 12(18) (2019-09-22)
A second-generation poly(propylene imine) dendrimer modified with acridine and its Cu(II) complex have been synthesized for the first time. It has been found that two copper ions form complexes with the nitrogen atoms of the dendrimeric core by coordinate bonds.
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