157945

(4-Carboxybutyl)triphenylphosphonium bromide

98%

• Synonym(s): 5-(Triphenylphosphonio)pentanoic acid bromide, Carboxybutyltriphenylphosphonium bromide, NSC 147756
• Linear Formula: (C₆H₅)₃P(Br)(CH₂)₄COOH
• CAS Number: 17814-85-6
• Molecular Weight: 443.31
• Beilstein: 3586477
• EC Number: 241-782-5
• MDL number: MFCD00011906
• UNSPSC Code: 12352107
• PubChem Substance ID: 24849711
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 98%
• form: powder
• reaction suitability: reaction type: C-C Bond Formation
• mp: 204-207 °C (lit.)
• functional group: carboxylic acid; phosphine
• SMILES string: [Br-].OC(=O)CCCC[P+](c1ccccc1)(c2ccccc2)c3ccccc3
• InChI: 1S/C23H23O2P.BrH/c24-23(25)18-10-11-19-26(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22;/h1-9,12-17H,10-11,18-19H2;1H
• InChI key: MLOSJPZSZWUDSK-UHFFFAOYSA-N

Description

Application

• Used as a platform for delivery of pro-apoptotic peptides into the mitochondria of tumor cells

Reactant for preparation of:

• Ring skeletons via ring closing metathesis and double bond migration ring closing metathesis reactions
• Methyl alkenyl quinolones as antimycobacterial agents
• Prostaglandins and their drug analogs via Gold-catalyzed Meyer-Schuster rearrangement
• Diphenylmethylpiperazines as N-type calcium channel blockers as potential therapeutic agents
• Folate receptor-specific glycinamide ribonucleotide formyltransferase (GARFTase) inhibitors with antitumor activity
• Cycloalkylidene alkanols with antileishmanial activity, via Wittig reaction

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H301,H318
• Precautionary Statements: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves