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1508901

USP

Pentoxifylline

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental

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About This Item

Empirical Formula (Hill Notation):
C13H18N4O3
CAS Number:
6493-05-6
Molecular Weight:
278.31
MDL number:
MFCD00063379
UNSPSC Code:
41116107
PubChem Substance ID:
329750705
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

pentoxifylline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

InChI key

MQGNNJQTNFHNHK-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Pentoxifylline USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Pentoxifylline Compounded Oral Suspension
  • Pentoxifylline Extended-Release Tablets

Biochem/physiol Actions

Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H362

Hazard Classifications

Acute Tox. 4 Oral - Lact.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Andrew B Jull et al.
The Cochrane database of systematic reviews, 12, CD001733-CD001733 (2012-12-14)
Healing of venous leg ulcers is improved by the use of compression bandaging but some venous ulcers remain unhealed, and some people are unsuitable for compression therapy. Pentoxifylline, a drug which helps blood flow, has been used to treat venous
Dan Shan et al.
The Cochrane database of systematic reviews, 2(2), CD006800-CD006800 (2012-02-18)
Diabetic kidney disease (DKD) is associated with increased morbidity and mortality, mostly relating to cardiovascular complications. The relevance of inflammation in the pathogenesis of DKD has been investigated in recent years, and it has been shown that inflammatory markers are
R Parker et al.
Alimentary pharmacology & therapeutics, 37(9), 845-854 (2013-03-16)
Acute alcoholic hepatitis (AH) is a severe manifestation of alcoholic liver disease with a grave prognosis. Pentoxifylline, an oral antitumour necrosis factor agent, has been reported to reduce mortality and incidence of hepatorenal syndrome (HRS) in severe alcoholic hepatitis (SAH).
Simone Appenzeller et al.
Rheumatology international, 31(11), 1511-1513 (2009-12-17)
Behcet's disease is an inflammatory disorder of unknown cause, characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. All these common manifestations are self-limiting except for the ocular attacks. The objective of the present study is to
Khalid N Haque et al.
The Cochrane database of systematic reviews, (10)(10), CD004205-CD004205 (2011-10-07)
Mortality and morbidity due to neonatal sepsis and necrotizing enterocolitis (NEC) is high despite the use of potent antimicrobial agents. Agents that modulate inflammation may improve outcomes. Pentoxifylline, a phosphodiesterase inhibitor, is one such agent. The primary objectives were to
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