SML0077

VU591

≥98% (HPLC)

• Synonym(s): 2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
• Empirical Formula (Hill Notation): C₁₆H₁₂N₆O₅
• CAS Number: 1222810-74-3
• Molecular Weight: 368.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825139
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥12 mg/mL
• storage temp.: 2-8°C
• SMILES string: [O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
• InChI: 1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)
• InChI key: ZQPXNYLXYNRFNP-UHFFFAOYSA-N
• Gene Information: human ... KCNJ1(3758)

Description

Application

VU591 may be used in cell signaling studies.

Biochem/physiol Actions

VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable