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SAB1305554

Sigma-Aldrich

MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse

clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

ACTB, Actin, cytoplasmic 1, Actin, cytoplasmic 1, N-terminally processed, Beta-actin

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

137CT26.1.1, monoclonal

form

buffered aqueous solution

mol wt

41737 Da

species reactivity

mouse, human

technique(s)

immunofluorescence: 1:10-1:50
immunohistochemistry: 1:25
western blot: 1:1000

isotype

IgG1κ

NCBI accession no.

NP_001092.1

UniProt accession no.

P60709

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ACTB(60)

General description

β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.

Application

Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.

Biochem/physiol Actions

β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sara Cuvertino et al.
American journal of human genetics, 101(6), 1021-1033 (2017-12-09)
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have
Induction of drug resistance in human hepatoma cells cultured on a silicate fiber based 3d scaffold
Mizutami T, et al.
Advances in Biochemical Engineering null
Sequence and structural analysis of beta-actin protein of fishes, using bioinformatics tools and techniques
Acharya UR, et al.
International journal of biosciences, 4(11) (2014)
Immacolata Andolfo et al.
Blood advances, 7(12), 2681-2693 (2023-01-04)
Gain-of-function mutations in PIEZO1 cause dehydrated hereditary stomatocytosis (DHS) or hereditary xerocytosis, an autosomal dominant hemolytic anemia characterized by high reticulocyte count, a tendency to macrocytosis, and mild jaundice, as well as by other variably penetrant clinical features, such as
Vincent Procaccio et al.
American journal of human genetics, 78(6), 947-960 (2006-05-11)
Actin, one of the major filamentous cytoskeletal molecules, is involved in a variety of cellular functions. Whereas an association between muscle actin mutations and skeletal and cardiac myopathies has been well documented, reports of human disease arising from mutations of
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