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C4428

Sigma-Aldrich

Cathepsin G from human leukocytes

lyophilized powder, ≥60 units/mg protein (Bradford)

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About This Item

CAS Number:
Enzyme Commission number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human leucocytes

Quality Level

form

lyophilized powder

specific activity

≥60 units/mg protein (Bradford)

mol wt

23-30 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CTSG(1511)

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General description

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

Application

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

Biochem/physiol Actions

Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.
Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.

Unit Definition

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

Physical form

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Structure, function, and control of neutrophil proteinases
Travis J
The American Journal of Medicine, 84(6), 37-42 (1988)
Cathepsin G: roles in antigen presentation and beyond
Burster T, et al.
Molecular Immunology, 47(4), 658-665 (2010)
Delivery and therapeutic potential of human granzyme B
Kurschus FC and Jenne DE
Immunological Reviews, 235(1), 159-171 (2010)
P I Bird
Immunology and cell biology, 77(1), 47-57 (1999-04-02)
Caspase activation and apoptosis can be initiated by the introduction of serine proteinases into the cytoplasm of a cell. Cytotoxic lymphocytes have evolved at least one serine proteinase with specific pro-apoptotic activity (granzyme B), as well as the mechanisms to
A type VII collagen subdomain mutant is thermolabile and shows enhanced proteolytic degradability?Implications for the pathogenesis of recessive dystrophic epidermolysis bullosa?
Windler C, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(1), 52-59 (2017)

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