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B1502

Sigma-Aldrich

Brain Extract from bovine brain

Type I, Folch Fraction I

Synonym(s):

Brain Extract from Bovine

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

biological source

bovine brain

Quality Level

200

type

Type I

form

powder

lipid type

phosphoglycerides

storage temp.

−20°C

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General description

Brain extract has lipids, especially polyunsaturated fatty acids (PUFAs) at high level. Extract from substantia niagra and the striatum has high amount of iron.

Application

Brain Extract from bovine brain has been used:
  • to prepare small unilamellar vesicles
  • in lipid binding assay
  • to aid the recovery of phosphoinositides and also to terminate the reaction in phosphatidylinositol 5-phosphate (PtdIns5P) and PtdIns4P assay
  • in liposome and protein self-aggregation assays

Biochem/physiol Actions

Brain lipids are involved in cellular signal transduction, membrane organization, trafficking protein modification, interactions and energy storage.

Packaging

Sealed ampule.

Components

Contains phosphatidylinositol phosphatidylserine,other brain lipids.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Qing Lu et al.
Molecular biology of the cell, 22(22), 4268-4278 (2011-10-04)
Myosin X (MyoX) is an unconventional myosin that is known to induce the formation and elongation of filopodia in many cell types. MyoX-induced filopodial induction requires the three PH domains in its tail region, although with unknown underlying molecular mechanisms.
Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers
Low C, et al.
Biophysical Journal, 95(9), 4315-4323 (2008)
Nora Kuhlmann et al.
The Journal of biological chemistry, 291(11), 5484-5499 (2016-01-01)
Rho proteins are small GTP/GDP-binding proteins primarily involved in cytoskeleton regulation. Their GTP/GDP cycle is often tightly connected to a membrane/cytosol cycle regulated by the Rho guanine nucleotide dissociation inhibitor α (RhoGDIα). RhoGDIα has been regarded as a housekeeping regulator
Fei Ye et al.
eLife, 7 (2018-12-12)
INAD assembles key enzymes of the Drosophila compound eye photo-transduction pathway into a supramolecular complex, supporting efficient and fast light signaling. However, the molecular mechanism that governs the interaction between INAD and NORPA (phospholipase Cβ, PLCβ), a key step for
Jonathan P Giblin et al.
Molecular neurobiology, 56(4), 2524-2541 (2018-07-25)
The background K+ channel TRESK regulates sensory neuron excitability, and changes in its function/expression contribute to neuronal hyperexcitability after injury/inflammation, making it an attractive therapeutic target for pain-related disorders. Factors that change lipid bilayer composition/properties (including volatile anesthetics, chloroform, chlorpromazine
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