27555

Cloxacillin sodium salt

≥95.0% (HPLC)

• Synonym(s): 3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt, Syntarpen sodium salt
• Empirical Formula (Hill Notation): C₁₉H₁₇ClN₃NaO₅S
• CAS Number: 642-78-4
• Molecular Weight: 457.86
• Beilstein: 4103180
• EC Number: 211-390-9
• MDL number: MFCD00063568
• UNSPSC Code: 51102829
• PubChem Substance ID: 57648259
• NACRES: NA.85

Properties

• biological source: semisynthetic
• Quality Level: 200
• Assay: ≥95.0% (HPLC)
• form: powder or crystals
• impurities: ≤5% Total impurities (anhydrous)
• color: white to off-white
• antibiotic activity spectrum: Gram-positive bacteria
• Mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
• InChI: 1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);/q;+1/p-1/t13-,14+,17-;/m1./s1
• InChI key: SCLZRKVZRBKZCR-SLINCCQESA-M

Description

General description

Chemical structure: ß-lactam

Application

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness[1] and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria[2].

Biochem/physiol Actions

Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves