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327190

Sigma-Aldrich

Isobutyl nitrite

95%

Synonym(s):

2-Methylpropyl nitrite

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About This Item

Linear Formula:
(CH3)2CHCH2ONO
CAS Number:
542-56-3
Molecular Weight:
103.12
EC Number:
208-819-7
MDL number:
MFCD00002056
UNSPSC Code:
12352100
PubChem Substance ID:
24859648
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

100

Assay

95%

form

liquid

refractive index

n20/D 1.373 (lit.)

bp

66-67 °C (lit.)

density

0.87 g/mL at 25 °C (lit.)

functional group

O-nitroso
nitroso

storage temp.

2-8°C

SMILES string

CC(C)CON=O

InChI

1S/C4H9NO2/c1-4(2)3-7-5-6/h4H,3H2,1-2H3

InChI key

APNSGVMLAYLYCT-UHFFFAOYSA-N

Related Categories

General description

Isobutyl nitrite was extensively used as room odorizers.[1] It is a popular recreational drug.[2]

Application

Isobutyl nitrite was used to study inhalant-induced immunotoxicity.[3]

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Flam. Liq. 2 - Muta. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

-5.8 °F - closed cup

Flash Point(C)

-21 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW1099
MKCV7148
MKCW8786
MKCT4302
MKCT6640

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Lee S F Soderberg et al.
Toxicology letters, 132(1), 37-45 (2002-06-27)
Nitrite inhalant abuse has been correlated with HIV and Kaposi's sarcoma. Mouse models of inhalant exposure show immunosuppression and loss of immune cells. In the present study, isobutyl nitrite caused a dose-dependent loss of viability of a macrophage cell line.
M T C Pruijm et al.
Nederlands tijdschrift voor geneeskunde, 146(49), 2370-2373 (2003-01-04)
Two male students, aged 20 and 21 years, developed central cyanosis shortly after drinking 5 ml of 'poppers' (isobutyl nitrite). They presented with methaemoglobinaemia and were hospitalised. After treatment with oxygen and intravenous fluids they could be discharged in good
[Methemoglobinemia due to ingestion of isobutyl nitrite ('poppers')].
W G Zijlstra
Nederlands tijdschrift voor geneeskunde, 147(23), 1144-1144 (2003-06-26)
Inhaled isobutyl nitrite produced lung inflammation with increased macrophage TNF-alpha and nitric oxide production.
L S Soderberg et al.
Advances in experimental medicine and biology, 402, 187-189 (1996-01-01)
L S Soderberg et al.
Experimental hematology, 24(7), 848-853 (1996-06-01)
Isobutyl nitrite is representative of a group of inhalants abused primarily by male homosexuals; abuse of this drug may be a risk factor for AIDS or Kaposi's sarcoma. Using a 14-day exposure regimen, we previously reported that inhaled isobutyl nitrite
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