S9200
Anti-SORL1 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-LDLR class A repeats containing, Anti-LR11, Anti-LRP9, Anti-SORLA, Anti-SorLA-1, Anti-Sortilin-related receptor, Anti-gp250
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~250 kDa
species reactivity
rat, human
packaging
antibody small pack of 25 μL
concentration
~1.0 mg/mL
technique(s)
western blot: 1-2 μg/mL using rat cerebellum (S1 fraction)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SORL1(6653)
mouse ... Sorl1(20660)
rat ... Sorl1(300652)
General description
Sortilin related receptor 1 (SORL1), a multifunctional protein, is also known as SorLA-1, LR11, LRP9 and gp250. It is a type-I transmembrane protein highly expressed in neurons. This protein belongs to the low-density lipoprotein receptor family. It contains a transmembrane domain, a large extracellular domain and a short cytoplasmic tail. SORL1 gene is located on human chromosome 11q 23/24. This mosaic receptor contains a domain that shares similarity with the vacuolar protein sorting 10 (VPS10) and with the low-density lipoprotein receptor (LDLR) family of proteins.
Specificity
Anti-SORL1 (C-terminal) specifically recognizes rat SORL1.
Application
Anti-SORL1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Sortilin related receptor 1 (SORL1) protein plays a key role in intracellular protein transport and endocytosis, cell signaling and the proliferation and migration of smooth muscle cells. It acts as a receptor for lipoproteins, glial cell-line-derived neurotrophic factor (GDNF) and platelet-derived growth factor (PDGF). Expression of this protein is developmentally regulated, with high transcript levels found during morphogenesis. SORLA is involved in development of atherosclerosis and in Alzheimer′s disease (AD). It mediates the uptake of apolipoprotein E (ApoE)-rich lipoproteins and is markedly induced in atheroma. SORL1 is known to play a regulating role in trafficking and processing of the amyloid precursor protein (APP) in neuronal cells. In the Golgi, SorLA/LR11 binding of APP leads to sequestration of APP and thereby it blocks the processing to the beta-amyloid peptide.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Certificates of Analysis (COA)
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Vanessa Schmidt et al.
Cellular and molecular life sciences : CMLS, 74(8), 1475-1483 (2016-11-11)
Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues
Coding mutations in SORL 1 and A lzheimer disease
Vardarajan BN, et al.
Annals of Neurology, 77(2), 215-227 (2015)
Olav M Andersen et al.
Biochemistry, 45(8), 2618-2628 (2006-02-24)
SorLA/LR11 is a sorting receptor that regulates the intracellular transport and processing of the amyloid precursor protein (APP) in neurons. SorLA/LR11-mediated binding results in sequestration of APP in the Golgi and in protection from processing into the amyloid-beta peptide (Abeta)
Michael L Cuccaro et al.
Neurology. Genetics, 2(6), e116-e116 (2016-11-09)
To characterize the clinical and molecular effect of mutations in the sortilin-related receptor ( We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer disease (LOAD) families followed by functional studies of select variants. The phenotypic consequences associated
Badri N Vardarajan et al.
Annals of neurology, 77(2), 215-227 (2014-11-11)
Common single nucleotide polymorphisms in the SORL1 gene have been associated with late onset Alzheimer disease (LOAD), but causal variants have not been fully characterized nor has the mechanism been established. The study was undertaken to identify functional SORL1 mutations
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