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M6756

Sigma-Aldrich

Microperoxidase (MP-11) sodium salt

≥85% (HPLC)

Synonym(s):

Microperoxidase-11, heme undecapeptide of cytochrome c

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About This Item

Empirical Formula (Hill Notation):
C84H116FeN20O21S2
CAS Number:
Molecular Weight:
1861.92
UNSPSC Code:
12352204
NACRES:
NA.54

Assay

≥85% (HPLC)

form

powder

storage temp.

−20°C

Application

Microperoxidase (MP-11) has been used in a study to assess its electrochemistry by cyclic voltammetry with multi-walled carbon nanotubes (MWNTs). It has also been used in a study as a label to investigate electrochemical immunosensing.

Biochem/physiol Actions

The oxidation of methyl phenyl sulfide to methyl phenyl sulfoxide by Microperoxidase-11 was promoted by low concentrations of alcohol but inhibited by high levels in the solvent.

Other Notes

The proposed structure is the heme portion of the cytochrome c molecule with amino acids 11-21 still attached.

Preparation Note

Prepared by enzymatic degradation of equine heart cytochrome c.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K D Vandegriff et al.
British journal of pharmacology, 154(8), 1649-1661 (2008-06-10)
MP4 (Hemospan) is a Hb-based oxygen therapeutic agent, based on polyethylene-glycol (PEG) conjugation to Hb, undergoing clinical trials as an oxygen carrier. This study describes the functional interaction between MP4 and carbon monoxide (CO), as a CO delivery agent, and
J G Ma et al.
Biochemistry, 38(9), 2787-2795 (1999-03-03)
Resonance Raman and UV-visible absorption spectra show that nickel(II) microperoxidase-11 (NiMP-11) is four-coordinate in aqueous solution in the pH range from 1.0 to 13.0. In aqueous solutions of NiMP-11 in the absence of cetyltrimethylammonium bromide (CTAB), NiMP-11 is aggregated. In
The effect of solvent on the catalytic properties of microperoxidase-11.
O'Reilly, N.
Physiological Chemistry and Physics, 13, 5304-5313 (2011)
Direct electrochemistry of microperoxidase11 using carbon nanotube modified electrodes
Wang, M., et al.
Journal of Electroanalytical Chemistry (Lausanne Switzerland), 578, 121-127 (2005)
A heme-peptide as an ultrastructural tracer.
N Feder
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 18(12), 911-913 (1970-12-01)

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