D1819

Anti-DYRK1A (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A, Anti-MNB protein kinase, Anti-MNB/MNBH, Anti-Minibrain Drosophila homolog
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~86 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): western blot: 1-2 μg/mL using rat brain embryonic extract; western blot: 2-4 μg/mL using rat brain postnatal extract
• UniProt accession no.: Q13627
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... DYRK1A(1859) ; mouse ... Dyrk1a(13548) ; rat ... Dyrk1a(25255)

Description

General description

Dual-specificity tyrosine-phosphorylated regulated kinase 1A (DYRK1A), also known as minibrain/Mnb is a member of a growing family of Ser/Thr protein kinases termed dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). DYRKs also possess autophosphorylation activity on tyrosine residues, located on the YXY motif of the activation loop of the catalytic domain.

The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.

Application

Anti-DYRK1A (C-terminal) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.

DYRK1A phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves