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04473

2,4-Pyridinedicarboxylic acid

Name: 2,4-Pyridinedicarboxylic acid
Brand: SIGMA

≥98.0%

Synonym(s):

Lutidinic acid

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About This Item

Empirical Formula (Hill Notation):

C₇H₅NO₄

CAS Number:

499-80-9

Molecular Weight:

167.12

NACRES:

NA.25

PubChem Substance ID:

329747930

UNSPSC Code:

12352106

EC Number:

207-892-2

MDL number:

MFCD00006296

Beilstein/REAXYS Number:

131631

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Properties

Quality Segment

100

assay

≥98.0%, 98.0-102.0% (T)

InChI

1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)

InChI key

MJIVRKPEXXHNJT-UHFFFAOYSA-N

Description

Application

2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. . 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.

Line H Kristensen et al.

The FEBS journal, 279(11), 1905-1914 (2012-03-17)

Dynamic methylations and demethylations of histone lysine residues are important for gene regulation and are facilitated by histone methyltransferases and histone demethylases (HDMs). KDM5B/Jarid1B/PLU1 is an H3K4me3/me2-specific lysine demethylase belonging to the JmjC domain-containing family of histone demethylases (JHDMs). Several

Characterization of two carnation petal prolyl 4 hydroxylases.

Florina Vlad et al.

Physiologia plantarum, 140(2), 199-207 (2010-06-18)

Prolyl 4-hydroxylases (P4Hs) catalyze the proline hydroxylation, a major post-translational modification, of hydroxyproline-rich glycoproteins. Two carnation petal P4H cDNAs, (Dianthus caryophyllus prolyl 4-hydroxylase) DcP4H1 and DcP4H2, were identified and characterized at the gene expression and biochemical level in order to

Competitive inhibition of glutamate dehydrogenase reaction.

Rajarshi Choudhury et al.

FEBS letters, 581(14), 2733-2736 (2007-05-29)

Irrespective of their pyridine nucleotide specificity, all glutamate dehydrogenases share a common chemical mechanism that involves an enzyme bound 'iminoglutarate' intermediate. Three compounds, structurally related to this intermediate, were tested for the inhibition of purified NADP-glutamate dehydrogenases from two Aspergilli

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Global Trade Item Number

SKU	GTIN
143618-100G	04061838734921
143618-500G	04061832278599
04473-5G	04061838630681