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Key Documents

27227

Sigma-Aldrich

Ethyl acetate

puriss., meets analytical specification of Ph. Eur., BP, NF, ≥99.5% (GC)

Synonym(s):

EtOAc

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About This Item

Linear Formula:
CH3COOC2H5
CAS Number:
Molecular Weight:
88.11
Beilstein:
506104
EC Number:
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NB.11

vapor density

3 (20 °C, vs air)

Quality Level

vapor pressure

73 mmHg ( 20 °C)

grade

puriss.

Assay

≥99.5% (GC)

form

liquid

autoignition temp.

801 °F

quality

meets analytical specification of Ph. Eur., BP, NF

expl. lim.

2.2-11.5 %, 38 °F

impurities

residual solvents, complies
≤0.003% non-volatile matter
≤0.005% free acid (as CH3COOH)
≤0.01% methyl. comp.(as acetic acid methylester)
≤0.1% ethanol (GC)
≤0.1% water (Karl Fischer)
≤0.2% related subst. (GC)

refractive index

n20/D 1.371-1.373
n20/D 1.3720 (lit.)

bp

76.5-77.5 °C (lit.)

mp

−84 °C (lit.)

density

0.898-0.902 g/mL at 20 °C
0.894-0.898 g/mL at 25 °C
0.902 g/mL at 25 °C (lit.)

suitability

complies for appearance of solution
complies for reaction against H2SO4
corresponds for chromatography
passes test for identity (IR)

format

neat

SMILES string

CCOC(C)=O

InChI

1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3

InChI key

XEKOWRVHYACXOJ-UHFFFAOYSA-N

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Application


  • [Determination of 12 prohibited veterinary drug residues in pig urine by ultra high performance liquid chromatography-tandem mass spectrometry]: Ethyl acetate is utilized for sample preparation in this advanced method to detect drug residues in animal samples, emphasizing its role in veterinary pharmaceutical compliance (Wan et al., 2024).

  • Therapeutic effect of Ginkgetin on smoke-induced airway inflammation by down-regulating the c/EBPβ signaling pathway and CCL2 expression: This study explores the anti-inflammatory properties of Ginkgetin, where ethyl acetate is used in the extraction process, highlighting its utility in biomedical research (Tao et al., 2024).

  • Effect of methanol extract of Plectranthus esculentus N.E.Br tuber and its fractions on indices of benign prostatic hyperplasia in Wistar rats: Ethyl acetate is employed in the extraction of bioactive compounds for pharmacological studies, showing its critical role in therapeutic applications (Kanu et al., 2024).

  • Phytochemical evaluation of Ziziphus mucronata and Xysmalobium undulutum towards the discovery and development of anti-malarial drugs: Demonstrates the use of ethyl acetate in phytochemical screenings, contributing to the development of new anti-malarial medications (Buthelezi et al., 2024).

  • The First Records of the In Silico Antiviral and Antibacterial Actions of Molecules Detected in Extracts of Algerian Fir (Abies numidica De Lannoy) Using LC-MS/MS Analysis: This research utilizes ethyl acetate for extracting compounds from plants for antiviral and antibacterial testing, underscoring its importance in the study of natural products (Benouchenne et al., 2024).

Other Notes

The article number 27227-4X2.5L-M will be discontinued. Please order the single bottle 27227-2.5L-M which is physically identical with the same exact specifications.
The article number 27227-4X2.5L-R will be discontinued. Please order the single bottle 27227-2.5L-R which is physically identical with the same exact specifications.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

24.8 °F - closed cup

Flash Point(C)

-4 °C - closed cup


Certificates of Analysis (COA)

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Complete oxidation of CO, ethanol, and ethyl acetate over copper oxide supported on titania and ceria modified titania.
Larsson PO and Andersson A.
J. Catal., 179(1), 72-89 (1998)
K H Young et al.
Journal of clinical microbiology, 10(6), 852-853 (1979-12-01)
Ethyl acetate appears to be a satisfactory subsitute solvent for diethyl ether in the Formalin-ether sedimentation technique. In comparative studies, concentration of organisms with ethyl acetate was equal to or greater than that with diethyl ether. No distortion or alteration
Flavio G Rocha et al.
Biomaterials, 29(19), 2884-2890 (2008-04-09)
Our group has previously created a functional neointestine that is capable of restoring absorptive function. However, the endogenous level of vascular endothelial growth factor (VEGF) is markedly reduced in the construct compared to native bowel. Therefore, we wanted to locally
Tsukasa Horiyama et al.
PloS one, 9(9), e108642-e108642 (2014-09-27)
Escherichia coli produces the iron-chelating compound enterobactin to enable growth under iron-limiting conditions. After biosynthesis, enterobactin is released from the cell. However, the enterobactin export system is not fully understood. Previous studies have suggested that the outer membrane channel TolC
K J S Anand et al.
British journal of anaesthesia, 101(5), 680-689 (2008-08-30)
Relationships between plasma morphine concentrations and neonatal responses to endotracheal tube (ETT) suctioning are unknown in preterm neonates. Ventilated preterm neonates (n=898) from 16 centres were randomly assigned to placebo (n=449) or morphine (n=449). After an i.v. loading dose (100

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