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ABN2300C3

Sigma-Aldrich

Neuro-Chrom Pan Neuronal Marker Antibody-Rabbit, Cy3 Conjugate

Neuro-Chrom, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

CY3 conjugate

clone

polyclonal

species reactivity

mouse, rat

manufacturer/tradename

Neuro-Chrom

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

shipped in

wet ice

target post-translational modification

unmodified

General description

Antibodies to neuronal proteins have become critical tools for identifying neurons and discerning morphological characteristics in culture and complex tissue. While the labeling from classic histological techniques such as Golgi staining and modern molecular approaches such as GFP constructs yield excellent cytoarchitectural detail, these approaches are technically challenging and impractical for many neuroscience research needs. Neuron-specific antibodies are convenient precision tools useful in revealing cytoarchitecture, but are limited to the protein target distribution within the neuron, which may differ greatly from nucleus to soma to dendrite and axon. To achieve as complete a morphological staining as possible across all parts of neurons, Millipore has developed a polyclonal antibody blend that reacts against key somatic, nuclear, dendritic, and axonal proteins distributed across the pan-neuronal architecture that can then be detected by a single secondary antibody. This antibody cocktail has been validated in diverse methods, cell culture and immuno-histochemistry, giving researchers a convenient and specific qualitative and quantitative tool for studying neuronal morphology.

Specificity

Cat. # ABN2300C is specific to axons (neurites), dendrites, nucleus, and the cell body of neurons.
Reactivity with other species has not been determined.

Immunogen

Epitope: Whole Neuron Marker

Application

Neuro-Chrom Pan Neuronal Marker-Rabbit, Cy3 Conjugate is an antibody targeting the Pan Neuronal Marker protein, validated for use in ICC, IHC & IF.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Quality

Routinely tested Rat E18 cortex primary neurons in Immunocytochemistry.

Physical form

Polyclonal antibody cocktail blend conjugated to Cy3 in PBS buffer with 15mg/mL BSA and 0.05% NaN3

Storage and Stability

Maintain at 2-8°C for up to 1 year from date of receipt.

Analysis Note

Control
Rat E18 cortex primary neuron cell culture or mouse adult brain cryosections.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zoeb Jiwaji et al.
Nature communications, 13(1), 135-135 (2022-01-12)
Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and MAPTP301S tauopathy mice revealed that only Aß influenced expression of AD risk genes, but both
Paul S Baxter et al.
Cell reports, 34(12), 108882-108882 (2021-03-25)
Microglia, brain-resident macrophages, require instruction from the CNS microenvironment to maintain their identity and morphology and regulate inflammatory responses, although what mediates this is unclear. Here, we show that neurons and astrocytes cooperate to promote microglial ramification, induce expression of
Cayla E Jewett et al.
eLife, 12 (2023-01-20)
Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21 and elevated Pericentrin disrupt cilia-related molecules and pathways, and the

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