This product is suitable for in vitro binding assays. It is advisable to consult peer-reviewed literature on in vitro binding assays between sialyl Lewis x and E-selectins specifically. Publications such as "Sialyl Lewisx Glycomimetics as E- and P-Selectin Antagonists Targeting Hyperinflammation," in ACS Med. Chem. Lett. (16)1, 64–71, indicate that catch bonds formed between selectins and sialyl Lewis x can affect binding affinity based on static versus dynamic environments. This effect may present challenges in accurately quantifying in vitro binding, depending on the nature of the binding assay. Therefore, in vivo studies might be important for a more accurate assessment of biological activity.
565950
Sialyl Lewis x, Sodium Salt
Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins.
Synonym(s):
Sialyl Lewis x, Sodium Salt, SLe x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc, SLex, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc
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About This Item
Empirical Formula (Hill Notation):
C31H51N2NaO23
CAS Number:
Molecular Weight:
842.73
UNSPSC Code:
12352201
NACRES:
NA.79
MDL number:
Pricing and availability is not currently available.
Quality Segment
assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 2 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
N([C@H]1[C@@H](O[C@@](C[C@@H]1O)(O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@@H]([C@H](O[C@@H]3O[C@H]([C@H]([C@H]([C@@H]3O)O)O)C)[C@@H](NC(=O)C)C=O)[C@H](O)CO)O)C(=O)O)[C@H](O)[C@H](O)CO)C(=O)C
InChI
1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1
InChI key
LAQPKDLYOBZWBT-NYLDSJSYSA-N
General description
Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLex reduces injury following ischemia and reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLex is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.
Other Notes
Seekamp, A., et al. 1994. Am. J. Pathol.144, 592.
Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.
Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.
Lasky, L.A. 1992. Science 258, 964.
Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.
Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.
Lasky, L.A. 1992. Science 258, 964.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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This Item | |||
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| description Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. | description - | description - | description Donor substrate for N-acetylglucosaminyltransferases. Useful in the synthesis of aryl azide derivatives that can be used in the affinity labeling of glycosyltransferase and UDP-HexNAc pyrophosphorylase. |
| assay ≥95% (TLC) | assay - | assay ≥90% (HPLC) | assay ≥95% (HPLC) |
| solubility water: 2 mg/mL | solubility - | solubility - | solubility water: 50 mg/mL |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form solid | form - | form powder | form crystalline powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| color white | color - | color white to yellow | color white to off-white |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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