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218744

Sigma-Aldrich

Caspase-2 Inhibitor I

The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase-2 Inhibitor I, Z-VD(OMe)VAD(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):
C32H46FN5O11
Molecular Weight:
695.73
UNSPSC Code:
12352200
NACRES:
NA.54

Quality Level

Assay

≥95% (HPLC)
≥95% (TLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable and irreversible inhibitor of caspase-2 (ICH-1)
An irreversible inhibitor of caspase-2 (ICH-1).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-2
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH₂F*

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gregoli, P.A., and Bondurant, M.C. 1999. J. Cell Physiol. 178, 133.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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