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Key Documents

L031000

Sigma-Aldrich

Activator 42®

0.1 M

Synonym(s):

5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole Solution, 5-[3,5-Bis(trifluoromethyl)phenyl]-2H-tetrazole Solution, Activator 42® Solution

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About This Item

CAS Number:
UNSPSC Code:
41106305
NACRES:
NA.21

Quality Level

type

for DNA synthesis

product line

Proligo Reagents

storage condition

dry at room temperature

concentration

28-31 g/L (Activator 42 content, titration)

impurities

≤30 ppm water content (Karl Fischer)

color

clear

InChI

1S/C9H4F6N4/c10-8(11,12)5-1-4(7-16-18-19-17-7)2-6(3-5)9(13,14)15/h1-3H,(H,16,17,18,19)

InChI key

KKJFZIQEWZVVIV-UHFFFAOYSA-N

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Preparation Note

Acetonitrile / Activator 42 100 / 3 (v/w)

Other Notes

Activator solution, containing 5-(3,5-bis(trifluoromethyl)phenyl)-1H-tetrazole (Activator 42) in acetonitrile, are mixed with solutions of phosphoramidites during the extension step.
The activator reacts with the amidite group to form a highly reactive intermediate. The intermediate then forms an internucleotide bond with the detritylated 5′hydroxyl group of the growing oligonucleotide chain.

Legal Information

This product and it use is are covered under US Patent Number 7,897,758
Activator 42 is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

41.0 °F

Flash Point(C)

5 °C


Certificates of Analysis (COA)

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