440736
4-Thiouracil
97%
Synonym(s):
2-Hydroxy-4-mercaptopyrimidine
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About This Item
Empirical Formula (Hill Notation):
C4H4N2OS
CAS Number:
Molecular Weight:
128.15
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
97%
form
powder
mp
295 °C (dec.) (lit.)
solubility
1 M NaOH: soluble 50 mg/mL
SMILES string
Oc1nccc(S)n1
InChI
1S/C4H4N2OS/c7-4-5-2-1-3(8)6-4/h1-2H,(H2,5,6,7,8)
InChI key
OVONXEQGWXGFJD-UHFFFAOYSA-N
Related Categories
Application
4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Xiaoran Zou et al.
The journal of physical chemistry. B, 118(22), 5864-5872 (2014-05-14)
Intensified research interests are posed with the thionucleobase 4-thiouracil (4-TU), due to its important biological function as site-specific photoprobe to detect RNA structures and nucleic acid-nucleic acid contacts. By means of time-resolved IR spectroscopy and density functional theory (DFT) studies
P J Unrau et al.
Nature, 395(6699), 260-263 (1998-09-29)
The 'RNA world' hypothesis proposes that early life developed by making use of RNA molecules, rather than proteins, to catalyse the synthesis of important biological molecules. It is thought, however, that the nucleotides constituting RNA were scarce on early Earth.
Artem Khvorostov et al.
Photochemistry and photobiology, 81(5), 1205-1211 (2005-06-23)
Unimolecular phototautomeric reactions in 4-thiouracil, 1-methyl-4-thiouracil and 6-aza-4-thiouracil were studied using the matrix-isolation technique combined with infrared absorption spectroscopy. For monomers of these compounds, isolated in solid argon at 10 K, an intramolecular proton-transfer photoreaction was observed. Upon UV (lambda
Structure and tautomerism of the neutral and monoanionic forms of 4-thiouracil derivatives.
A Psoda et al.
Journal of the American Chemical Society, 96(22), 6832-6839 (1974-10-30)
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