390690

(2-Hydroxypropyl)-α-cyclodextrin

average M_w ~1,180

• Synonym(s): α‐HPCD, 2OHpαCD, 2‐hydroxypropyl‐α‐CD, HPαCD, HP-α-CD
• CAS Number: 128446-33-3
• MDL number: MFCD00197866
• UNSPSC Code: 12352201
• NACRES: NA.22

Properties

• form: powder
• Quality Level: 100
• optical activity: [α]20/D +125°, c = 1 in H₂O
• mol wt: average M_w ~1,180
• extent of labeling: 0.6 molar substitution
• mp: 245 °C (dec.) (lit.)

Description

General description

(2-Hydroxypropyl)-α-cyclodextrin is a hydroxyalkyl derivative of cyclodextrin, which is generally used as a substitute of α-cyclodextrin for potential application in food, cosmetics and pharmaceutical industries. It may be used as a parenteral drug carrier on account of its attractive characteristics such as: a greater extent of solubility in water, high dissolution capacity for weakly soluble analytes, and low toxicity.

Application

• (2-Hydroxypropyl)-α-cyclodextrin can be used as a chiral selector to resolve tryptophan racemate by capillary electrophoresis.
• It can be used to synthesize biodegradable polyrotaxanes for fabricating blood-contacting devices.
• Co-polymer based on (2-hydroxypropyl)-α-cyclodextrin cross-linked with polyethylenimine can be used as a gene delivery vector.
• It can also be used as stabilizer for antibacterial iodine formulations, as it forms a stable inclusion complex with iodine and improves aqueous solubility.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves