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Key Documents

WH0283455M1

Sigma-Aldrich

Monoclonal Anti-KSR2 antibody produced in mouse

clone 6F12, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-FLJ25965, Anti-kinase suppressor of ras 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6F12, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

NM_173598

UniProt accession no.

Q6VAB6

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KSR2(283455)

Related Categories

General description

Kinase suppressor of ras 2 (KSR2) is a scaffolding protein.

Immunogen

KSR2 (NP_775869, 411 a.a. ~ 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
PAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEV

Biochem/physiol Actions

Kinase suppressor of ras 2 (KSR2) has a role in the growth and proliferation of breast tumor cells. It takes part in signaling pathways and associates with calcineurin.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
07222-6F12

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Laura R Pearce et al.
Cell, 155(4), 765-777 (2013-11-12)
Kinase suppressor of Ras 2 (KSR2) is an intracellular scaffolding protein involved in multiple signaling pathways. Targeted deletion of Ksr2 leads to obesity in mice, suggesting a role in energy homeostasis. We explored the role of KSR2 in humans by
M Jia et al.
Experimental oncology, 32(3), 209-212 (2011-03-16)
To study the expression of Kinase Suppressor of Ras 2 (KSR2) in human breast tumors and its effect on proliferation of breast epithelial cells. We reported previously that KSR2 was up-regulated in immortalized human breast epithelial cells. Proteomics technologies, systems
E Giurisato et al.
Molecular biology of the cell, 25(11), 1769-1781 (2014-03-29)
Store-operated calcium entry (SOCE) is the predominant Ca(2+) entry mechanism in nonexcitable cells and controls a variety of physiological and pathological processes. Although significant progress has been made in identifying the components required for SOCE, the molecular mechanisms underlying it

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