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T6700

Sigma-Aldrich

TRAM-34

≥98% (HPLC), solid

Synonym(s):

1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

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About This Item

Empirical Formula (Hill Notation):
C22H17ClN2
CAS Number:
289905-88-0
Molecular Weight:
344.84
MDL number:
MFCD09842562
UNSPSC Code:
12352200
PubChem Substance ID:
329826852
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: 2 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4

InChI

1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H

InChI key

KBFUQFVFYYBHBT-UHFFFAOYSA-N

Application

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem/physiol Actions

TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.
TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H Wulff et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(14), 8151-8156 (2000-07-08)
The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome
Zhihua Yu et al.
Frontiers in cellular neuroscience, 11, 319-319 (2017-10-28)
Ischemic stroke is a devastating neurological disease that can initiate a phenotype switch in astrocytes. Reactive astrogliosis is a significant pathological feature of ischemic stroke and is accompanied by changes in gene expression, hypertrophied processes and proliferation. The intermediate-conductance Ca
Friederike A Steudel et al.
Molecular oncology, 11(9), 1172-1188 (2017-05-31)
Oncogenic signalling via Ca
K George Chandy et al.
Trends in pharmacological sciences, 25(5), 280-289 (2004-05-04)
The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The channel phenotype changes during the progression from the resting to
Huike Yang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46(2), 765-780 (2018-04-06)
Based on the protective effect of crocin against cardiovascular diseases, we hypothesize that crocin could improve endothelial function through activating the eNOS(endothelial nitric oxide synthase) /NO pathway and/or the intermediate-conductance Ca2+-activated K+ channels (KCa3.1). In this study, rat aortic rings
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