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Key Documents

T5824

Sigma-Aldrich

TAN-67 dihydrobromide

≥98% (HPLC), solid

Synonym(s):

(3-Hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide, SB-205607 dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C23H24N2O · 2HBr
CAS Number:
Molecular Weight:
506.27
MDL number:
UNSPSC Code:
12352200

description

Store tightly sealed under nitrogen

Assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: soluble >20 mg/mL

storage temp.

2-8°C

SMILES string

Br[H].Br[H].[H][C@@]12CN(C)CC[C@]1(Cc3nc4ccccc4cc3C2)c5cccc(O)c5

Biochem/physiol Actions

Potent, selective non-peptide δ opioid receptor agonist.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Hemal H Patel et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16(11), 1468-1470 (2002-09-03)
Opioids and volatile anesthetics produce marked cardioprotective effects against myocardial infarction via the activation of ATP-sensitive potassium (K(ATP)) channels, however, the effect of combined treatment with both drugs is unknown. We examined the hypothesis that opioids and volatile anesthetics potentiate
R M Fryer et al.
The Journal of pharmacology and experimental therapeutics, 299(2), 477-482 (2001-10-17)
We investigated the possibility that opioids activate a tyrosine kinase (TK) that mediates cardioprotection in an in vivo rat model of myocardial infarction. All animals underwent 30 min of regional ischemia and 2 h of reperfusion. Infarct size was expressed

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