SML3422

Pritelivir

≥98% (HPLC)

• Synonym(s): AIC316, BAY 57-1293, BAY57-1293, N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide
• Empirical Formula (Hill Notation): C₁₈H₁₈N₄O₃S₂
• CAS Number: 348086-71-5
• Molecular Weight: 402.49
• MDL number: MFCD18633192
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(N)c1[s]c(nc1C)N(C)C(=O)Cc2ccc(cc2)c3ncccc3
• InChI: 1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)
• InChI key: IVZKZONQVYTCKC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor with antiviral efficacy in cultures and in mice in vivo.

Pritelivir (AIC316; BAY57-1293) is a potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor (IC50 = 30 nM using wt HSV-1F ATPase complex UL5-UL52 & 1 mM ATP) with antiviral efficacy in Vero cultures (replication IC50 = 20 nM against HSV-2G, wt and Acyclovir-resistant HSV-1F; MOI = 0.0025) and in mice in vivo (ED50 = 0.5 mg/kg 3x daily p.o. using HSV-1 Walki or HSV-2 MS), being >28 times more potent than acyclovir and valacyclovir.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable