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SML2124

Sigma-Aldrich

Ned-K

≥98% (HPLC)

Synonym(s):

(1R,3S)-1-(3-((4-(2-Cyanophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

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5 MG
NOK 1,230.00
25 MG
NOK 3,960.00

NOK 1,230.00

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5 MG
NOK 1,230.00
25 MG
NOK 3,960.00

About This Item

Empirical Formula (Hill Notation):
C31H31N5O3
CAS Number:
2250019-90-8
Molecular Weight:
521.61
MDL number:
MFCD30742938
UNSPSC Code:
12352200
NACRES:
NA.77

NOK 1,230.00

Please contact Customer Service for Availability

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

Ned-K is a specific and potent inhibitor of NAADP (nicotinic acid adenine dinucleotide phosphate) signaling that suppresses Ca2+ oscillations via two-pore channels (TPC1) and opening of the mitochondrial permeability transition pore (mPTP) in cardiomyocytes during simulated ischaemia and reperfusion. Ned-K protected cardiomyocytes from cell death during ischaemia and reperfusion injury in rats.
specific and potent inhibitor of NAADP (nicotinic acid adenine dinucleotide phosphate) signaling that suppresses Ca2+ oscillations

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Sean M Davidson et al.
Cardiovascular research, 108(3), 357-366 (2015-09-24)
In the heart, a period of ischaemia followed by reperfusion evokes powerful cytosolic Ca(2+) oscillations that can cause lethal cell injury. These signals represent attractive cardioprotective targets, but the underlying mechanisms of genesis are ill-defined. Here, we investigated the role

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