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SML0175

Sigma-Aldrich

Pyrovalerone hydrochloride

≥98% (HPLC)

Synonym(s):

1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride, Centroton, F 1983, Sp 1059, Thymergix

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About This Item

Empirical Formula (Hill Notation):
C16H23NO·HCl
CAS Number:
1147-62-2
Molecular Weight:
281.82
EC Number:
214-556-9
UNSPSC Code:
41116107
NACRES:
NA.77
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Assay

≥98% (HPLC)

form

powder

drug control

psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

color

off-white to light brown

solubility

H2O: ≥5 mg/mL at 60 °C

storage temp.

2-8°C

InChI

1S/C16H23NO.ClH/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14;/h7-10,15H,3-6,11-12H2,1-2H3;1H

InChI key

MWRACNBZNVAJHE-UHFFFAOYSA-N

Application

Pyrovalerone hydrochloride may be used in dopamine-mediated cell signaling studies.

Biochem/physiol Actions

Pyrovalerone hydrochloride is a CNS Stimulant; norepinephrine-dopamine reuptake inhibitor (NDRI)
Pyrovalerone hydrochloride is a rapidly-absorbed psychostimulant. It belongs to the class of synthetic cathinones often used as performance-enhancing agent by athletes before being banned.[1][2]
Pyrovalerone is a norepinephrine-dopamine reuptake inhibitor (NDRI) that acts as a CNS stimulant.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H336

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
101M4620V

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Peter C Meltzer et al.
Journal of medicinal chemistry, 49(4), 1420-1432 (2006-02-17)
Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research because the modulation of their production and their interaction at monoamine receptors has profound effects upon a multitude
Jane M Prosser et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(1), 33-42 (2011-11-24)
Synthetic cathinones have recently emerged and grown to be popular drugs of abuse. Their dramatic increase has resulted in part from sensationalized media attention as well as widespread availability on the Internet. They are often considered "legal highs" and sold
H S Shin et al.
Journal of analytical toxicology, 20(7), 568-572 (1996-11-01)
Detection and identification of pyrovalerone and its metabolite, a hydroxylated product, are described. Their identities were confirmed by comparing their mass spectra and gas chromatographic retention times with those of the synthetic standards. The analytical method of pyrovalerone and its
The metabolism of pyrovalerone hydrochloride.
W Michaelis et al.
Journal of medicinal chemistry, 13(3), 497-503 (1970-05-01)
Sabina Strano-Rossi et al.
Rapid communications in mass spectrometry : RCM, 24(18), 2706-2714 (2010-09-04)
A method for the toxicological screening of the new designer drug methylenedioxypyrovalerone (MDPV) is described; with an emphasis on its application for anti-doping analysis. The metabolism of MDPV was evaluated in vitro using human liver microsomes and S9 cellular fractions
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