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SAB4502671

Sigma-Aldrich

Anti-RPL39, N-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

60S ribosomal protein L39

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 6 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:60000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P62891

UniProt accession no.

P62891

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RPL39(6170)

General description

Ribosomal protein L39 (RPL39), a component of the 60S ribosomal complex. The RPL39 gene is mapped on human chromosome XQ24.

Immunogen

The antiserum was produced against synthesized peptide derived from human RPL39.

Immunogen Range: 1-50

Biochem/physiol Actions

Ribosomal protein L39 (RPL39) plays a major role in spermatogenesis and translation. It might participate in ribosome biogenesis. Mutations in the RPL39 gene are associated with breast cancer and lung metastasis. RPL39 is capable of disrupting nitric oxide synthase and hypoxia signaling pathway. Overexpression of RPL39 can enhance wound-healing in MDAMB231 and BT549 cells. Antibody detects endogenous levels of total RPL39 protein.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Bhuvanesh Dave et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(24), 8838-8843 (2014-05-31)
We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) and myeloid leukemia factor 2 (MLF2) as the top candidates that affect BCSC self-renewal. Knockdown of

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