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SAB4501013

Sigma-Aldrich

Anti-OPN3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ECPN, Encephalopsin, OPN3, Opsin-3, Panopsin

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... OPN3(23596)

General description

Anti-OPN3 Antibody detects endogenous levels of total OPN3 protein.
Opsin 3 (OPN3) is also termed as encephalopsin or panopsin. It is a member of the encephalopsin/tmt-opsin subfamily. It is expressed in brain, liver, placenta, heart and pancreatic tissues. The OPN3 gene is located on human chromosome 1q43.

Immunogen

The antiserum was produced against synthesized peptide derived from human OPN3.

Immunogen Range: 161-210

Biochem/physiol Actions

Opsin3 controls the apoptotic pathway and makes hepatocellular carcinoma cells fragile to 5-fluorouracil treatment. OPN3 plays an important role in oncogenesis and drug resistance. It also plays crucial roles in various physiological and pathological processes.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Multiple hits for the association of uterine fibroids on human chromosome 1q43.
Aissani B, et al.
PLoS ONE, 8(3), e58399-e58399 (2013)
Encephalopsin (OPN3) protein abundance in the adult mouse brain.
Nissila J, et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 198(11), 833-839 (2012)
Bioinformatic Analysis of Human OPN3 Alternative Promoters Associated with Cancer.
Al-Obaide MA, et al.
Applied Mathematics & Information Sciences, 10, 1223-1229 (2016)
Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway.
Jiao J, et al.
Cancer Letters, 320(1), 96-103 (2012)
Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats.
Huang, et al.
Acta Cirurgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa em Cirurgia, 38, e380223-e380223 (2023)

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