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SAB4200328

Sigma-Aldrich

Anti-acetyl-Histone H3 [Ac-Lys56]

IgG fraction of antiserum

Synonym(s):

Anti-H3.4, Anti-H3/g, Anti-H3FT, Anti-H3K56ac, Anti-H3t, Anti-HIST3H3

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About This Item

UNSPSC Code:
12352203

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~15 kDa

species reactivity

rat, human, mouse

technique(s)

western blot: 1:1000-1:2000 using NIH3T3 or HeLa cell lysates

UniProt accession no.

Q16695

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

acetylation (Lys56)

Gene Information

human ... HIST3H3(8290)

General description

Histones are considered as the important constituents of chromatin. They are classified into core histones and linker histones. Histone H3 gene codes for a H3 protein sequence. This H3 gene is located on human chromosome 1 (1q42).

Immunogen

synthetic peptide containing acetylated Lys56 of human histone H3, conjugated to KLH. The corresponding sequence is identical in many species including rat and mouse histone H3.

Application

Anti-acetyl-Histone H3 [Ac-Lys56] has been used in western blot analysis.

Biochem/physiol Actions

Core histones and linker histones are known possesses inter and intra-specific amino acid sequence variability. Histone modifications are thought to play an important role in cancer and disease. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. In human embryonic stem cells, histone H3 Lys56 acetylation is associated to the core transcriptional network.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Xie W, et al.
Molecular Cell, 33(4), 417-427 (2009)
A solitary human H3 histone gene on chromosome 1
Albig W, et al.
Human Genetics, 97(4), 486-491 (1996)
Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae
Azad GK, et al.
PLoS ONE, 8(3), e59003-e59003 (2013)
Histone Variants: Signaling or Structural Modules
Handbook of Cell Signaling, 2409-2425 (2010)
Shraddha Chauhan et al.
Environmental science and pollution research international, 31(20), 30149-30162 (2024-04-11)
Nanoparticles, particularly magnesium oxide nanoparticles (MgO-NPs), are increasingly utilized in various fields, yet their potential impact on cellular systems remains a topic of concern. This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae
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