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SAB2106014

Sigma-Aldrich

Anti-CRBN, (N-terminal) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-DKFZp781K0715, Anti-MGC27358, Anti-MRT2A

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100 μL
NOK 4,190.00

NOK 4,190.00

Please contact Customer Service for Availability
A recombinant, preservative-free antibody is available for your target. Try ZRB1304
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100 μL
NOK 4,190.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

NOK 4,190.00

Please contact Customer Service for Availability
A recombinant, preservative-free antibody is available for your target. Try ZRB1304

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

50 kDa

species reactivity

rabbit, human, horse, bovine, mouse, guinea pig, rat

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NM_016302

UniProt accession no.

Q96SW2

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CRBN(51185)

Immunogen

Synthetic peptide directed towards the N terminal region of human CRBN

Sequence

Synthetic peptide located within the following region: DQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVL

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC39899
QC27896

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Jing Fang et al.
Nature medicine, 22(7), 727-734 (2016-06-14)
Despite the high response rates of individuals with myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)) to treatment with lenalidomide (LEN) and the recent identification of cereblon (CRBN) as the molecular target of LEN, the cellular mechanism by which
Yuen Lam Dora Ng et al.
Journal of medicinal chemistry, 66(7), 4703-4733 (2023-03-31)
Proteolysis targeting chimeras (PROTACs) represent a new pharmacological modality to inactivate disease-causing proteins. PROTACs operate via recruiting E3 ubiquitin ligases, which enable the transfer of ubiquitin tags onto their target proteins, leading to proteasomal degradation. However, several E3 ligases are

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