Gfl-1 encodes a C. elegans ortholog of human Glioma-amplified sequence-41 (GAS41), found in increased copy number in low-grade glioma. Loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism. GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors.
Immunogen
GFL (NP_502172, ) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of C. Elegans Gfl-1.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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