S6069

Sp 5,6-DCl-cBIMPS

≥98% (HPLC), solid

• Synonym(s): 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole-3′,5′-cyclic monophosphorothioate, Sp- isomer sodium salt
• Empirical Formula (Hill Notation): C₁₂H₁₀Cl₂N₂O₅PSNa
• CAS Number: 120912-54-1
• Molecular Weight: 419.15
• MDL number: MFCD06795834
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724615

Properties

• Assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: H₂O: 1 mM; DMSO: freely soluble; ethanol: freely soluble
• shipped in: dry ice
• storage temp.: −70°C
• SMILES string: [Na+].O[C@@H]1[C@@H]2O[P@]([S-])(=O)OC[C@H]2O[C@H]1n3cnc4cc(Cl)c(Cl)cc34

Description

Application

Sp 5,6-DCl-cBIMPS may be used in cAMP-dependent protein kinase-mediated cell signaling studies.

Biochem/physiol Actions

Selective cAMP-dependent protein kinase (PKA) activator. Especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves