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P4023

Sigma-Aldrich

Phenyl N-acetyl-α-D-galactosaminide

≥98%

Synonym(s):

Phenyl 2-acetamido-2-deoxy-α-D-galactopyranoside

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About This Item

Empirical Formula (Hill Notation):
C14H19NO6
CAS Number:
Molecular Weight:
297.30
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:

Assay

≥98%

storage temp.

2-8°C

SMILES string

CC(=O)NC1C(O)C(O)C(CO)OC1Oc2ccccc2

General description

Phenyl-N-acetyl-α-D-galactosaminide is a competitive inhibitor of N-acetyl-α-D-galactose and N-acetylneuraminic acid transferases.

Application

Phenyl N-acetyl-α-D-galactosaminide has been used in a study to treat papillae in order to assess regeneration of broken tip links and restoration of mechanical transduction in hair cells. It has also been used in a study to inhibit N- and mucin-like O-glycosylation in order to investigate a novel transmembrane serine protease overexpressed in pancreatic cancer.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H Sadeghi et al.
Glycobiology, 9(7), 731-737 (1999-06-11)
The human V2 vasopressin receptor contains one consensus site for N-linked glycosylation at asparagine 22 in the predicted extracellular amino terminal segment of the protein. This segment also contains clusters of serines and threonines that are potential sites for O-glycosylation.
Y Zhao et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(26), 15469-15474 (1996-12-24)
A hair cell's tip links are thought to gate mechanoelectrical transduction channels. The susceptibility of tip links to acoustic trauma raises questions as to whether these fragile structures can be regenerated. We broke tip links with the calcium chelator 1,2-bis(O-aminophenoxy)
N Gross et al.
Medical and pediatric oncology, 36(1), 139-141 (2001-07-24)
CD44 represents a heterogeneous group of surface glycoproteins involved in cell-cell and cell-matrix interactions. CD44H is the major receptor for hyaluronate, and most if not all CD44H known functions are attributed to its ability to recognize hyaluronate. We have previously
C Wallrapp et al.
Cancer research, 60(10), 2602-2606 (2000-05-29)
We report the characterization of a novel serine protease of the chymotrypsin family, recently isolated by cDNA-representational difference analysis, as a gene overexpressed in pancreatic cancer. The 2.3-kb mRNA of the gene, named TMPRSS3, is strongly expressed in a subset

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