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P3892

Sigma-Aldrich

Poly-L-arginine hydrochloride

suitable for bioconjugations, Mol wt >70,000

Synonym(s):

L-Arginine homopolymer hydrochloride

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About This Item

CAS Number:
26982-20-7
MDL number:
MFCD00166393
UNSPSC Code:
12352209
PubChem Substance ID:
24898466
NACRES:
NA.26

product name

Poly-L-arginine hydrochloride, mol wt >70,000

form

powder or solid

mol wt

>70,000

technique(s)

bioconjugation: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

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Application

Poly-L-arginine hydrochloride has been used:
  • as polyelectrolyte solution in the synthesis of biodegradable capsules
  • as layer constituent, in the preparation of layer by layer (LbL) assembly of multilayer biodegradable shells
  • in assay for the determination of binding activity of C-reactive protein for polycationic ligands

Biochem/physiol Actions

Poly-L-arginine (PLA) possesses anti-bacterial activity. It has a greater capacity to enhance membrane permeability. PLA at lower concentration enhances cell proliferation and at higher concentration acts as antiproliferative agent.

Quality

Contains 3% or less ornithine residue by TLC.

Analysis Note

Molecular weight based on viscosity of precursor poly-L-ornithine.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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NIR-light triggered delivery of macromolecules into the cytosol
Carregal-Romero S, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 159(1), 120-127 (2012)
Multilayered Magnetic Nanobeads for the Delivery of Peptides Molecules Triggered by Intracellular Proteases
Quarta A, et al.
ACS Applied Materials & Interfaces, 9(40), 35095-35104 (2017)
Poly-L-arginine: Enhancing Cytotoxicity and Cellular Uptake of Doxorubicin and Necrotic Cell Death
Movafegh B, et al.
Anticancer Agents in Medicinal Chemistry, 18(10), 1448-1456 (2018)
Interaction of Calcium-bound C-reactive Protein with Fibronectin Is Controlled by pH IN VIVO IMPLICATIONS
Suresh MV, et al.
Test, 279(50), 52552-52557 (2004)
Antibacterial activity of poly-l-arginine under different conditions
Sepahi M , et al.
Iranian Journal of Microbiology, 9(2), 103-103 (2017)
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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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