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Key Documents

O0766

Sigma-Aldrich

ONO-RS-082

≥97% (HPLC)

Synonym(s):

2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid, 4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid

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5 MG
NOK 884.00
25 MG
NOK 3,270.00

NOK 884.00

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5 MG
NOK 884.00
25 MG
NOK 3,270.00

About This Item

Empirical Formula (Hill Notation):
C21H22ClNO3
CAS Number:
99754-06-0
Molecular Weight:
371.86
UNSPSC Code:
41106300
NACRES:
NA.77

NOK 884.00

Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥97% (HPLC)

form

powder

shelf life

Do not freeze

storage condition

protect from light

color

white

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

Clc1cc(c(cc1)C(=O)O)NC(=O)\C=C\c2ccc(cc2)CCCCC

InChI

1S/C21H22ClNO3/c1-2-3-4-5-15-6-8-16(9-7-15)10-13-20(24)23-19-14-17(22)11-12-18(19)21(25)26/h6-14H,2-5H2,1H3,(H,23,24)(H,25,26)/b13-10+

InChI key

MDVFITMPFHDRBZ-JLHYYAGUSA-N

Biochem/physiol Actions

ONO-RS-082 is a reversible phospholipase A2 inhibitor.

Features and Benefits

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
090M4727V
0000145648
0000039915
0000039914

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Rania Abu-Hamdah et al.
Cell biology international, 28(1), 7-17 (2004-02-05)
Aquaporins (AQP) are involved in rapid and active gating of water across biological membranes. The molecular regulation of AQP is unknown. Here we report the isolation, identification and reconstitution of the regulatory complex of AQP-1. AQP-1 and Galphai3 have been
Y Li et al.
American journal of physiology. Heart and circulatory physiology, 280(6), H2658-H2664 (2001-05-18)
Physiological concentrations of [Arg(8)]vasopressin (AVP; 10-500 pM) stimulate oscillations of cytosolic free Ca2+ concentration (Ca2+ spikes) in A7r5 vascular smooth muscle cells. We previously reported that this effect of AVP was blocked by a putative phospholipase A2 (PLA2) inhibitor, ONO-RS-082
H Yoshida et al.
The American journal of physiology, 273(3 Pt 1), G735-G747 (1997-10-08)
In an attempt to examine the structure-activity relationship of the cholecystokinin (CCK) peptide, we examined the structural motif of CCK truncated peptides responsible for rat pancreatic acinar amylase secretion and signal transduction. CCK-6 (Met28-Gly29-Trp30-Met31-Asp32-Phe33 -NH2), CCK-5 [CCK-(29-33)], and CCK-4 [CCK-(30-33)]
K L Byron
Circulation research, 78(5), 813-820 (1996-05-01)
[Arg8]-vasopressin (AVP) is both a potent vasoconstrictor and a mitogen for vascular smooth muscle cells. AVP binds to a single class of receptors (V1a) in the A7r5 rat aortic smooth muscle cell line (Kd approximately 2 nmol/L). Stimulation of these
Y Sugita et al.
European journal of pharmacology, 365(1), 77-89 (1999-02-13)
In order to examine some possibly misleading conclusions of the pharmacological analysis of the signal transduction pathways of gastric acid secretion, we evaluated various agents including inhibitors of protein kinase C, cyclic AMP-dependent protein kinase, phospholipase C, phospholipase A2, lipoxygenase
View All Related Papers

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Phospholipase A2

Phospholipase A2 (PLA2) enzymes hydrolyze glycerophospholipids, yielding arachidonic acid; inhibition targets eicosanoid biosynthesis.

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