Skip to Content
Merck
All Photos(1)

Key Documents

O0766

Sigma-Aldrich

ONO-RS-082

≥97% (HPLC)

Synonym(s):

2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid, 4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
NOK 884.00
25 MG
NOK 3,270.00

NOK 884.00

Please contact Customer Service for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
NOK 884.00
25 MG
NOK 3,270.00

About This Item

Empirical Formula (Hill Notation):
C21H22ClNO3
CAS Number:
99754-06-0
Molecular Weight:
371.86
UNSPSC Code:
41106300
NACRES:
NA.77

NOK 884.00

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥97% (HPLC)

form

powder

shelf life

Do not freeze

storage condition

protect from light

color

white

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

Clc1cc(c(cc1)C(=O)O)NC(=O)\C=C\c2ccc(cc2)CCCCC

InChI

1S/C21H22ClNO3/c1-2-3-4-5-15-6-8-16(9-7-15)10-13-20(24)23-19-14-17(22)11-12-18(19)21(25)26/h6-14H,2-5H2,1H3,(H,23,24)(H,25,26)/b13-10+

InChI key

MDVFITMPFHDRBZ-JLHYYAGUSA-N

Biochem/physiol Actions

ONO-RS-082 is a reversible phospholipase A2 inhibitor.

Features and Benefits

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
090M4727V
0000145648
0000039915
0000039914

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

M Fukunaga et al.
Experimental nephrology, 4(6), 340-349 (1996-11-01)
The phospholipase A2 inhibitors mepacrine, ONO-RS-082, and AACOCF3 completely inhibited prostaglandin E2 production induced by endothelin 1 in cultured rat mesangial cells, suggesting that phospholipase A2 is a critical enzyme in this process. TMB-8, an inhibitor of calcium mobilization from
H Nishino et al.
The American journal of physiology, 274(3 Pt 1), G525-G534 (1998-04-08)
We investigated the structural requirements for bombesin (BB)-like peptides to stimulate amylase secretion in rat pancreatic acini and examined the responsible intracellular signal transduction pathways. The tetradecapeptide BB-(1-14) was a full agonist, whereas the heptapeptide BB-(8-14) did not evoke amylase
Azharul Islam et al.
Cellular signalling, 17(4), 507-523 (2004-12-17)
2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid (PACA), pharmacological inhibitor of phospholipase A(2) (PLA(2)), inhibits epinephrine-stimulated thromboxane production in human platelets. In this study, we investigated the effect of PACA on meiotic maturation individually in stages V and VI oocytes. PACA prevented the maturation in
Rania Abu-Hamdah et al.
Cell biology international, 28(1), 7-17 (2004-02-05)
Aquaporins (AQP) are involved in rapid and active gating of water across biological membranes. The molecular regulation of AQP is unknown. Here we report the isolation, identification and reconstitution of the regulatory complex of AQP-1. AQP-1 and Galphai3 have been
Y Li et al.
American journal of physiology. Heart and circulatory physiology, 280(6), H2658-H2664 (2001-05-18)
Physiological concentrations of [Arg(8)]vasopressin (AVP; 10-500 pM) stimulate oscillations of cytosolic free Ca2+ concentration (Ca2+ spikes) in A7r5 vascular smooth muscle cells. We previously reported that this effect of AVP was blocked by a putative phospholipase A2 (PLA2) inhibitor, ONO-RS-082
View All Related Papers

Articles

Phospholipase A2

Phospholipase A2 (PLA2) enzymes hydrolyze glycerophospholipids, yielding arachidonic acid; inhibition targets eicosanoid biosynthesis.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service