M7782
Antiflammin-1
≥97% (HPLC)
Synonym(s):
Anti-inflammatory peptide 1, Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser
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About This Item
Empirical Formula (Hill Notation):
C45H82N12O14S2
CAS Number:
Molecular Weight:
1079.33
MDL number:
UNSPSC Code:
12352200
Assay
≥97% (HPLC)
composition
Peptide content, ~70%
storage temp.
−20°C
SMILES string
CSCCC(N)C(=O)NC(CCC(N)=O)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(O)=O
Biochem/physiol Actions
Inhibits synthesis of platelet activating factor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions.
G Camussi et al.
Advances in experimental medicine and biology, 279, 161-172 (1990-01-01)
Jennifer L Beal et al.
Biochemistry, 48(46), 11142-11148 (2009-10-21)
Electrophilic halogenating agents, including hypohalous acids and haloamines, oxidize free methionine and the N-terminal methionines of peptides and proteins (e.g., Met-1 of anti-inflammatory peptide 1 and ubiquitin) to produce dehydromethionine (a five-membered isothiazolidinium heterocycle). Amide derivatives of methionine are oxidized
Inhibition of phospholipase A2 by uteroglobin and antiflammin peptides.
L Miele et al.
Advances in experimental medicine and biology, 279, 137-160 (1990-01-01)
David B Rivers et al.
Toxicon : official journal of the International Society on Toxinology, 40(1), 9-21 (2001-10-17)
The mode of action of venom from the ectoparasitic wasp Nasonia vitripennis in eliciting cell death was examined using an in vitro approach with BTI-TN-5B1-4 cells, and the cell responses were compared to those evoked by the extensively studied wasp
Jianzhong Han et al.
Cell biology international, 32(9), 1108-1115 (2008-06-11)
Antiflammin-1 (AF-1) is a synthetic nonapeptide with a similar sequence to the conserved sequence of CC10 secreted by lung Clara cells. Studies suggest that it is potent inhibitor of inflammation. We investigated the effects and possible mechanisms of AF-1 on
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