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Key Documents

COO/COA

EMU090051

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting mouse Abcg2

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About This Item

UNSPSC Code:

41105324

NACRES:

NA.51

description

Quality Level

100

product line

MISSION^®

form

lyophilized powder

esiRNA cDNA target sequence

TGTGGAGCTGTTCGTAGTGGAGAAGAAACTCTTCATACATGAGTACATCAGTGGATATTACAGAGTGTCTTCTTACTTCTTTGGAAAGGTGATGTCTGATTTACTCCCCATGAGGTTCTTGCCAAGTGTTATATTCACTTGTATATTATACTTCATGTTAGGACTGAAGAAGACGGTGGATGCTTTTTTCATCATGATGTTTACCCTTATAATGGTGGCTTATACGGCCAGTTCCATGGCACTGGCCATAGCCACAGGCCAAAGTGTGGTGTCTGTAGCAACACTTCTCATGACAATCGCTTTTGTATTTATGATGCTCTTTTCTGGCCTCTTGGTGAATCTCAGAACCATTGGGCCTTGGCTGTCCTGGCTTCAGTACTTTAGCATTCCTCGATATGGCTTCACAGCTTTGCAGTATAATGAATTCTTGGGACAAGAGTTTTGTCCAGGATTCAATGTAACGGACAACAGCACTTGTGTTAACAGCTATGCAATATGTACTGGTAACGAGTACTTGATAAATCAGGGCATCGAACTGTCACCTTGGGGACTG

Ensembl | mouse accession no.

ENSMUSG00000029802

NCBI accession no.

NP_036050

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... ABCG2(26357) , Abcg2(26357)

Related Categories

MISSION® esiRNA

Oligos, qPCR Probes & Peptides

General description

MISSION^® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Transcriptional targeting of human liver carboxylesterase (hCE1m6) and simultaneous expression of anti-BCRP shRNA enhances sensitivity of breast cancer cells to CPT-11.

Mukti N Mishra et al.

Anticancer research, 34(11), 6345-6351 (2014-11-05)

The major factor limiting the efficacy of breast cancer chemotherapy is multidrug resistance due to overexpression of the breast cancer resistance protein ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2). We hypothesized that conversion of camptothecin-11 (CPT-11) to its highly

2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cell-specific drug transporters with acquired cisplatin resistance in cisplatin sensitive cancer cells.

Tuvshinjargal Gotovdorj et al.

Journal of Korean medical science, 29(9), 1188-1198 (2014-09-24)

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce drug transporter genes such as the ATP-binding cassette G member 2 (ABCG2), which contributes to multidrug resistance. We investigated the effect of TCDD pretreatment on drug transporters induction from cancer cells of various origins. Cell viabilities

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