Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

A2027

Sigma-Aldrich

L-Arginine-7-amido-4-methylcoumarin hydrochloride

cathepsin H substrate

Synonym(s):

Arginine 4-methyl-7-coumarylamide

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
NOK 1,010.00
25 MG
NOK 3,470.00

NOK 1,010.00

Please contact Customer Service for Availability
All Photos(1)

Select a Size

Change View
5 MG
NOK 1,010.00
25 MG
NOK 3,470.00

About This Item

Empirical Formula (Hill Notation):
C16H21N5O3
CAS Number:
69304-16-1
Molecular Weight:
331.37
MDL number:
MFCD00058184
UNSPSC Code:
12352204
PubChem Substance ID:
24890618
NACRES:
NA.83

NOK 1,010.00

Please contact Customer Service for Availability

Quality Level

200

Assay

≥97% (TLC)

form

powder

solubility

acetic acid: water (1:1): 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@@H](N)CCCNC(N)=N)ccc12

InChI

1S/C16H21N5O3.ClH/c1-9-7-14(22)24-13-8-10(4-5-11(9)13)21-15(23)12(17)3-2-6-20-16(18)19;/h4-5,7-8,12H,2-3,6,17H2,1H3,(H,21,23)(H4,18,19,20);1H/t12-;/m0./s1

InChI key

PFLMUQNBZRXRHD-YDALLXLXSA-N

Looking for similar products? Visit Product Comparison Guide

Application

L-Arginine-7-amido-4-methylcoumarin hydrochloride has been used as a substrate for cathepsin H from rat muscle homogenate[1] and sarcoplasmic extract.[2] It has also been used as a substrate for arginine amino-peptidase from Daphnia homogenates[3] and recombinant aminopeptidase from Toxoplasma gondii.[4]

Biochem/physiol Actions

L-Arginine-7-amido-4-methylcoumarin hydrochloride is a protease substrate.[5] It is a specific substrate for cathepsin H and not for cathepsin L and B.[6]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
061K1315V
061K1315
090K1233
062H0892
033H0724

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

4-Methylumbelliferone ≥98%

Sigma-Aldrich

M1381

4-Methylumbelliferone

Wonnop Visessanguan et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 134(3), 477-487 (2003-03-12)
A predominant, heat-activated proteinase in muscle extract of arrowtooth flounder (Atheresthes stomias) was purified to 55-fold by heat treatment, followed by a series of chromatographic separations. The apparent molecular mass of the purified enzyme was 27 kDa by size exclusion
Emilia M Marijanovic et al.
The Biochemical journal, 477(19), 3819-3832 (2020-09-15)
Toxoplasmosis is a parasitic disease caused by infection with Toxoplasma gondii that currently has few therapeutic options. The M1 aminopeptidase enzymes have been shown to be attractive targets for anti-parasitic agents and/or vaccine candidates, suggesting potential to re-purpose inhibitors between
Natália Angelo da Silva Miyaguti et al.
Biomolecules, 9(6) (2019-06-16)
Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich
Xiaofei Tian et al.
BMC evolutionary biology, 19(1), 122-122 (2019-06-15)
Several genetic lineages of obligate parthenogenetic Daphnia pulex, a common zooplankton species, have invaded Japan from North America. Among these, a lineage named JPN1 is thought to have started colonization as a single genotype several hundred to thousand years ago
Bei-Wei Zhu et al.
Bioscience, biotechnology, and biochemistry, 72(6), 1430-1437 (2008-06-10)
Cathepsin L-like enzyme was purified from the body wall of the sea cucumber Stichopus japonicus by an integral method involving ammonium sulfate precipitation and a series of column chromatographies on DEAE Sepharose CL-6B, Sephadex G-75, and TSK-GEL. The molecular mass
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service