The Journal of organic chemistry, 76(20), 8262-8269 (2011-09-09)
A POCl(3)-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional group compatibility because of the metal-free, acidic reaction conditions. The yields
Chemistry, an Asian journal, 6(12), 3298-3305 (2011-07-23)
POCl(3)-mediated one-pot macrocyclization allows the highly selective formation of five-residue macrocycles that are rigidified by internally placed intramolecular hydrogen bonds. Mechanistic investigation by using tailored competition experiments and kinetic simulation provides a comprehensive model, supporting a chain-growth mechanism underlying the
Escherichia coli alkaline phosphatase (AP) is the prototypical two metal ion catalyst with two divalent zinc ions bound approximately 4 A apart in the active site. Studies spanning half a century have elucidated many structural and mechanistic features of this
Angewandte Chemie (International ed. in English), 51(31), 7688-7691 (2012-06-26)
Three for one: Pyrrolyldipyrromethenes having different functional groups were efficiently synthesized from POCl(3)-promoted condensations between 5-chloro-2-formylpyrrole or isoindole derivatives and suitable pyrrole or indole fragments through a novel nucleophilic aromatic substitution of the initially formed protonated azafulvene rings.
Journal of hazardous materials, 172(1), 276-279 (2009-08-12)
1,2-Bis(2,4,6-trinitrophenyl) hydrazine (3) is one of the precursors in the synthesis of an important energetic material viz., hexanitrazobenzene. The simple and convenient lab scale synthesis of title compound (3) was carried out by the condensation of picryl chloride (2) with
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