475828
β₂-Microglobulin, Human, Recombinant, E. coli
Synonym(s):
rhβ₂M
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.25
Recommended Products
form
lyophilized
Quality Level
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
solubility
aqueous buffer: soluble
shipped in
wet ice
storage temp.
−20°C
General description
Recombinant, human β2-microglobulin fused at the N-terminus to a His•Tag sequence and expressed in E. coli. Subsequently cleaved with CNBr to remove the His•Tag sequence. Extracellular protein that is non-covalently associated with the α-chains of class I MHC molecules. Used as a marker for various tumors and for kidney disease. The purified protein functions similarly to the native protein in in vitro models of amyloid fibril extension.
Recombinant, human β2-microglobulin fused at the N-terminus to a His•Tag sequence and expressed in E. coli. Subsequently cleaved with CNBr to remove the His•Tag sequence. Extracellular protein that is non-covalently associated with the α-chains of class I MHC molecules. Used as a marker for various tumors and for kidney disease. The purified protein functions similarly to the native protein in in vitro models of amyloid fibril extension.
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Analysis Note
single band by SDS-PAGE
Other Notes
Sugg, S.V., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 6613.
Berggard, I., and Bearn, G. 1968. J. Biol. Chem. 243, 4095.
Berggard, I., and Bearn, G. 1968. J. Biol. Chem. 243, 4095.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Naomi Issler et al.
Journal of the American Society of Nephrology : JASN, 33(4), 732-745 (2022-02-13)
The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and cargo are incompletely understood. EHD1 belongs to a family of
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