263275
Desmosine
A novel quaternary pyridinium poly-amino acid present in elastin.
Synonym(s):
Desmosine
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About This Item
Empirical Formula (Hill Notation):
C24H39N5O8
Molecular Weight:
525.60
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥99% (TLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A novel quaternary pyridinium poly-amino acid present in elastin. Suggested to be responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity.
A novel quaternary pyridinium poly-amino acid present in elastin. Suggested to be responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity. Absorption max: 268 nm.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Cross-linking of elastin
Cross-linking of elastin
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Akagawa, M., and Suyama, K. 2000. Connect. Tissue Res.41, 131.
Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap.13, 175.
Viglio, S., et al. 2000. Eur. Respir. J.15, 1039.
Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc.92, 3778.
Thomas, J., et al. 1963. Nature200, 651.
Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap.13, 175.
Viglio, S., et al. 2000. Eur. Respir. J.15, 1039.
Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc.92, 3778.
Thomas, J., et al. 1963. Nature200, 651.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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