178196

α₁-Antichymotrypsin, Human Plasma

Acute-phase protein present at ~45 mg/100 ml in plasma.

• Synonym(s): α₁-Antichymotrypsin, Human Plasma, α₁-Achy, α₁-1X, α₁-1X-Glycoprotein
• CAS Number: 141176-92-3
• MDL number: MFCD00162030
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (SDS-PAGE)
• form: solid
• specific activity: ≥85%, pH 7.4, 25 °C (using Suc-Ala-Ala-Pro-Phe-pNA as substrate, inhibition of cathepsin G)
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: aqueous buffer: soluble
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Acute-phase protein present at 45 mg/100 ml in plasma. Specific inhibitor of chymotrypsin-like serine proteinases.

Acute-phase protein present at ~45 mg/100 ml in plasma. Specific inhibitor of chymotrypsin-like serine proteinases. Molecular weight ranges from 65,000-68,000 daltons.

M.W. 65,000-68,000.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Chymotrypsin-like serine proteases

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 150 mM NaCl, 20 mM Tris-HCl, pH 7.4.

Preparation Note

Please refer to vial label for lot-specific volume prior to lyophilization.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for at up to 6 months at -20°C.

Other Notes

Desrochers, P.E., et al. 1992. J. Biol. Chem.267, 5005.
Rayford, A., et al. 1992. J.Neurochem.58, 88.
Travis, J., et al. 1978. Biochemistry17, 5651.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable