116818
Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt
A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA).
Synonym(s):
Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt, Sp-8-Br-cAMPS, Na
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About This Item
Empirical Formula (Hill Notation):
C10H10BrN5O5PS · Na
Molecular Weight:
446.15
UNSPSC Code:
12352200
Quality Level
Assay
≥99% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
solubility
water: 40 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent cell-permeable, metabolically stable activator of cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell permeable than Sp-cAMPS (Cat. No. 116815). λmax = 264 nm (H2O, pH 7.0); εmax = 17,000 M-1cm-1. Note: 5 µmol = 2.23 mg.
A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA). Induces guanine nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell-permeable than Sp-cAMPS (Cat. No. 116815). Note: 5 µmol = 2.23 mg.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKA
PKA
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
Schaap, P., et al. 1993. J. Biol. Chem.268, 6323.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.
de Rooij, J., et al. 1998. Nature 396, 474.
Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
Schaap, P., et al. 1993. J. Biol. Chem.268, 6323.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.
Legal Information
Sold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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