06-676
Anti-mGluR2/3 Antibody
Upstate®, from rabbit
Synonym(s):
Anti-GLUR2, Anti-MGLUR2, Anti-mGlu2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
rat ... Grm2(24415)
Specificity
mGluR2 and mGluR3
Immunogen
peptide (KQFVPTVCNGREVVDSTTSSL) corresponding to amino acids 853-872 of human metabotropic glutamate receptor 2
Application
Anti-mGluR2/3 Antibody is an antibody against mGluR2/3 for use in IH, IP & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurodegenerative Diseases
Neurotransmitters & Receptors
Neurodegenerative Diseases
Quality
routinely evaluated by immunoblot on rat brain microsomal preparation
Target description
100-110kDa
Physical form
0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol
Format: Purified
Protein A chromatography
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus.
Shigemoto, R, et al.
The Journal of Neuroscience, 17, 7503-7522 (1997)
L Emile et al.
Neuropharmacology, 35(5), 523-530 (1996-05-01)
Glutamic acid is the major excitatory amino acid of the central nervous system which interacts with two receptor families, the ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGluRs) are coupled to G proteins and can be divided into
Yoshiaki Miyamoto et al.
The international journal of neuropsychopharmacology, 20(12), 1027-1035 (2017-10-12)
Several clinical studies have suggested that N-acetylaspartate and N-acetylaspartylglutamate levels in the human brain are associated with various psychiatric disorders, including major depressive disorder. We have previously identified Shati/Nat8l, an N-acetyltransferase, in the brain using an animal model of psychosis.
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.
Dhanya, RP; Sheffler, DJ; Dahl, R; Davis, M; Lee, PS; Yang, L; Nickols, HH; Cho et al.
Journal of medicinal chemistry null
M Behnam Ghasemzadeh et al.
Pharmacology, biochemistry, and behavior, 92(3), 383-392 (2009-01-13)
Glutamatergic neurotransmission plays an important role in the behavioral and molecular plasticity observed in cocaine mediated locomotor sensitization. Recent studies show that glutamatergic signaling is regulated by receptor trafficking, synaptic localization, and association with scaffolding proteins. The trafficking of the
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