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850338P

Avanti

MAPCHO™-14

n-tetradecylphosphocholine, powder

Synonym(s):

TPC; Fos-Choline-14; FOS14; FC-14

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About This Item

Empirical Formula (Hill Notation):
C19H42NO4P
CAS Number:
77733-28-9
Molecular Weight:
379.51
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850338P-1g)
pkg of 1 × 10 g (850338P-10g)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850338P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C19H42NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-23-25(21,22)24-19-17-20(2,3)4/h5-19H2,1-4H3

InChI key

BETUMLXGYDBOLV-UHFFFAOYSA-N

General description

MAPCHO™-14 is a fos-choline-based zwitterionic detergent.
Tetradecylphosphocholine is a structural analog of myristoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification. It has been used as a helper lipid for in vitro and in vivo gene transfer, and it has been shown to have some anticancer activity.

Application

MAPCHO™-14 has been used as a supplement in extraction buffer (RIPA buffer).

Biochem/physiol Actions

Fos-choline-14 (N-tetradecylphosphocholine) is mainly used for solubilization and purification of proteins.

Packaging

20 mL Clear Glass Screw Cap Vial (850338P-1g)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (850338P-10g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line
Cook BL, et al.
Testing, 3(8), e2920-e2920 (2008)
Brian L Cook et al.
PloS one, 3(8), e2920-e2920 (2008-08-07)
In order to begin to study the structural and functional mechanisms of olfactory receptors, methods for milligram-scale purification are required. Here we demonstrate the production and expression of a synthetically engineered human olfactory receptor hOR17-4 gene in a stable tetracycline-inducible
Pernille M Christensen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(6), 2351-2359 (2016-03-10)
Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1
Christensen PM, et al.
Faseb Journal, 30(6), 2351-2359 (2016)
Julia Koehler et al.
Biochemistry, 49(33), 7089-7099 (2010-07-30)
There has been a renewal of interest in interactions of membrane proteins with detergents and lipids, sparked both by recent results that illuminate the structural details of these interactions and also by the realization that some experimental membrane protein structures
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