810230P
Avanti
C6-NBD Safingol
Avanti Research™ - A Croda Brand 810230P, powder
Synonym(s):
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-L-threo-sphinganine
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About This Item
Empirical Formula (Hill Notation):
C30H51N5O6
CAS Number:
Molecular Weight:
577.76
UNSPSC Code:
12352211
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (810230P-50ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810230P
shipped in
dry ice
storage temp.
−20°C
General description
Safingol belongs to the lysosphingolipid class and is the synthetic L-threo-stereoisomer of (D-erythro-) sphinganine.
Biochem/physiol Actions
Safingol, a competitive inhibitor of sphingosine kinase 1, exhibits anticancer activity. It is known to increase antitumor activity of cisplatin in xenograft experiments.
Packaging
5 mL Amber Glass Screw Cap Vial (810230P-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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Mark A Dickson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(8), 2484-2492 (2011-01-25)
Sphingosine 1-phosphate (S1P) is an important mediator of cancer cell growth and proliferation. Production of S1P is catalyzed by sphingosine kinase 1 (SphK). Safingol, (l-threo-dihydrosphingosine) is a putative inhibitor of SphK. We conducted a phase I trial of safingol (S)
Jesse Coward et al.
Autophagy, 5(2), 184-193 (2008-12-23)
Safingol, the synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine, is an inhibitor of protein kinase C and sphingosine kinase in vitro, and in some cell types has been implicated in ceramide generation and induction of apoptosis. Utilizing electron microscopy, acridine orange
Synthesis of threo-beta-aminoalcohols from aminoaldehydes via chelation-controlled additions. Total synthesis of l-threo sphingosine and safingol
Jung ME and Yi SW
Tetrahedron Letters, 53(32), 4216-4220 (2012)
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